Fig. 5
From: Copper-catalyzed remote C(sp3)–H azidation and oxidative trifluoromethylation of benzohydrazides
Mechanistic studies on the oxidative δ-trifluoromethylation of 2-alkyl benzohydrazides. a Control experiment; b KIE experiment; c isoindolinone formation; d possible reaction pathway; conditions: 10 or 6 or 3a/3a-D2 (0.1 mmol), Togni’s reagent 9 (0.3 mmol), CuCl (0.04 mmol), DCM (1.0 mL, c 0.1 M), Na2CO3 (0.3 mmol), rt, 4 h
