Fig. 8
From: STAT1 signaling shields T cells from NK cell-mediated cytotoxicity
Innate STAT1 expression is required to eliminate Stat1−/− T cells. a Representative flow cytometry plots of CD4+ T cells in the spleen of WT and Stat1−/− mice followed by their mean frequencies ± SEM. b WT (CD45.1+) or Stat1−/− (CD45.2+) CD4+ T cells were injected i.p. at a 1:1 ratio (1 × 106/type) into Stat1−/−Rag1−/− mice or their Stat1+/−Rag1−/− littermate controls and analyzed after 3 weeks. Representative images of CD45.1+ vs CD45.2+ cells (gated on live CD45+ CD3ε+ CD4+ T cells) from various organs are shown followed by their mean frequencies ± SEM. Pooled from three independent experiments, with each point representing an individual mouse. ***p < 0.001, ****p < 0.0001 by two-tailed Mann–Whitney test
