Fig. 6
From: Morphologic determinant of tight junctions revealed by claudin-3 structures
Mechanism for determining the flexibility of TJ strands by TM3 bending. a Proline renders TM3 bent, as seen in the mCldn3cryst structure, with the formation of a narrow cis-interaction pocket. The narrow pocket would restrict the orientation of the cis-interaction, resulting in linear TJ strands having little flexibility. b The alanine or glycine renders TM3 straight, as seen in mCldn3cryst P134A or P134G structure, with the formation of a wide cis-interaction pocket. The wide pocket would enable wide orientation range, resulting in curvy TJ strands with high flexibility. Hydrophobic interactions in cis-interaction are represented in green. TJ strands are depicted according to the anti-parallel double-row model
