Fig. 3 | Nature Communications

Fig. 3

From: Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01

Fig. 3

Structural analysis of 2E3 allele specificity. a Amino acid sequence alignment of HLA-A*11:01 with selected HLA alleles at the 2E3 epitope. b Magnified view of the interaction between HLA α chain Asp90 and 2E3 VL. Asp90 was duplicated and mutated to Ala90 (cyan). c Magnified view of the interaction between HLA α chain Arg14 and 2E3 VH. Arg14 was duplicated and mutated to Trp14 (cyan). d Magnified view of the interaction between HLA α chain Arg17 and 2E3 VH. Arg17 was duplicated and mutated to Ser17 (cyan). e Magnified view of the interaction between HLA α chain Glu19 and 2E3 VH. Glu19 was duplicated and mutated to Lys19 (cyan). f Magnified view of the interaction between HLA α chain Asp39 and 2E3 VH. Asp39 was duplicated and mutated to Tyr39 (cyan). HLA human leukocyte antigens

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