Fig. 2
From: Hydrophobic chirality amplification in confined water cages
Enantioselectivity of the Mannich product depending on catalyst hydrophobicity and stirring rate. a Chiral catalysts used in this study. b Effect of catalyst hydrophobicity on enantioselectivity. Conditions: 1a (0.3 mmol), 2 (0.6 mmol), catalyst (1 mol%), and brine (2.0 mL)/toluene (15 equiv) or CH2Cl2 (2.0 mL). c Effect of stirring speed on enantioselectivity. Conditions: 1a–1c (0.3 mmol), 2 or 4 (0.6 mmol), catalyst (1 mol%), and brine (2.0 mL)/toluene (15 equiv). For experimental details regarding controlling the stirring speed, see the Supplementary Figure 1. Enantiomeric excess (% ee) was determined by high-performance liquid chromatography (HPLC). *The Log P values (the P value is a n-octanol/water partition coefficient) of catalysts were calculated using ChemBioDraw Ultra 12.0 software
