Table 1 Validation of the iCell rewired genes
Gene, breast cancer | Literature support | Patient survival curve diff. (p-val) | Cell viability change (p-val) | Gene, prostate cancer | Literature support | Patient survival curve diff. (p-val) | Cell viability change (p-val) |
|---|---|---|---|---|---|---|---|
XKR3 | PMID: 19592507 | 4.57E-01 | 4.04E-02 | NPIPA8 | 1.91E-01 | ||
TOPAZ1 | PMID: 23478628 | 4.04E-02 | CBWD5 | 6.43E-03 | 3.31E-01 | ||
HLA-DQA2 | PMID: 27539887 | 4.06E-03 | XKR3 | PMID: 19592507 | 4.04E-02 | ||
ECT2L | intOgen | 2.88E-02 | 5.00E-01 | TOPAZ1 | PMID: 23478628 | 4.04E-02 | |
CD300LD | 4.04E-02 | HLA-DQA2 | PMID: 27539887 | 7.67E-02 | |||
GDF6 | PMID: 17616940 | 1.13E-01 | 4.04E-02 | ECT2L | intOgen | 2.32E-01 | 5.00E-01 |
PNMA6A | 2.14E-02 | 4.04E-02 | RNF222 | PMID: 24974835 | 1.70E-01 | 1.91E-01 | |
MAGEB16 | PMID: 11454705 | 4.04E-02 | SIGLEC14 | 1.02E-01 | 1.91E-01 | ||
ERICH6B | PMID: 26828653 | 6.77E-03 | 4.04E-02 | PNMA6A | 5.75E-03 | 4.04E-02 | |
NAE1 | PMID: 22874562 | 3.22E-02 | 4.04E-02 | MAGEB16 | PMID: 11454705 | 4.04E-02 | |
NTRK1 | intOgen | 5.89E-03 | 4.04E-02 | PLEKHN1 | PMID: 24004954 | 2.08E-02 | 4.04E-02 |
CCNB1 | PMID: 27903976 | 4.12E-02 | 4.04E-02 | CACTIN | PMID: 20829348 | 7.22E-03 | 4.04E-02 |
MRPL3 | 1.75E-02 | 4.04E-02 | KANK2 | PMID: 26739330 | 1.17E-01 | 4.04E-02 | |
PSMC3 | 2.01E-02 | 4.04E-02 | HPS6 | 4.23E-01 | 5.00E-01 | ||
MRPL50 | 6.17E-02 | 4.04E-02 | ANAPC16 | 2.11E-01 | 1.91E-01 | ||
CD300LG | 2.38E-02 | 4.04E-02 | TNXB | PMID: 26090390 | 2.17E-01 | 4.04E-02 | |
C9orf163 | 4.04E-02 | ARHGAP23 | PMID: 23535730 | 3.67E-02 | 4.04E-02 | ||
MRPL4 | 3.33E-01 | 4.04E-02 | DGCR14 | 1.05E-01 | 4.04E-02 | ||
COPS5 | intOgen | 1.90E-03 | 5.00E-01 | UBE2H | 1.13E-01 | 1.91E-01 | |
MRPL42 | 9.32E-02 | 1.91E-01 | MAZ | PMID: 25449683 | 6.39E-03 | 4.04E-02 |
Gene, lung cancer | Literature support | Patient survival curve diff. (p-val) | Cell viability change (p-val) | Gene, colorectal cancer | Literature support | Patient survival curve diff. (p-val) | Cell viability change (p-val) |
|---|---|---|---|---|---|---|---|
TOPAZ1 | PMID:23478628 | 4.04E-02 | HLA-DQA2 | PMID: 27539887 | 1.21E-01 | ||
HLA-DQA2 | PMID:27539887 | 2.57E-02 | ECT2L | intOgen | 2.52E-02 | 9.52E-02 | |
ECT2L | intOgen | 2.44E-02 | 1.91E-01 | PNMA6A | 2.32E-02 | 4.04E-02 | |
VCP | PMID: 18798739 | 1.13E-02 | 4.04E-02 | MAGEB16 | PMID: 11454705 | 4.04E-02 | |
ARID3A | PMID: 22469780 | 1.38E-01 | 4.04E-02 | ERICH6B | PMID: 26828653 | 3.80E-02 | 3.31E-01 |
H6PD | 5.18E-02 | 4.04E-02 | ARHGEF33 | 1.95E-01 | 3.31E-01 | ||
RIC8A | 2.13E-03 | 9.52E-02 | SARDH | PMID:23824605 | 2.31E-02 | 4.04E-02 | |
ALG13 | 6.55E-03 | 3.31E-01 | PLEKHN1 | PMID:24004954 | 9.03E-02 | 4.04E-02 | |
FEM1B | PMID: 19908242 | 3.27E-01 | 5.00E-01 | ZNF777 | PMID:25560148 | 1.17E-02 | 3.31E-01 |
RPL6 | PMID: 22043320 | 3.74E-01 | 4.04E-02 | C9orf163 | 4.04E-02 | ||
ACBD3 | PMID: 20043945 | 1.25E-01 | 9.52E-02 | UBE2H | 5.67E-03 | 1.91E-01 | |
PELI3 | 1.94E-01 | 4.04E-02 | KLC3 | 3.07E-04 | 9.52E-02 | ||
ATP6V1H | PMID: 25659576 | 2.01E-01 | 3.31E-01 | CLDN4 | 2.25E-01 | 4.04E-02 | |
RIF1 | PMID: 19483192 | 1.86E-01 | 3.31E-01 | CDH22 | PMID: 19546606 | 3.10E-01 | 4.04E-02 |
RBM25 | 4.22E-02 | 4.04E-02 | CAB39 | 2.17E-02 | 9.52E-02 | ||
ANKZF1 | 3.87E-02 | 4.04E-02 | CNR1 | 4.61E-02 | 9.52E-02 | ||
ATRX | intOgen | 1.15E-02 | 5.00E-01 | HTR4 | 7.74E-02 | 9.52E-02 | |
ABCA2 | 1.13E-02 | 4.04E-02 | EXOC5 | 1.82E-02 | 5.00E-01 | ||
PTK2 | PMID: 27175819 | 1.27E-01 | 4.04E-02 | TMPRSS4 | 1.19E-02 | 4.04E-02 | |
MMAA | 3.98E-01 | 3.31E-01 | ADARB1 | 8.16E-05 | 1.91E-01 |
