Fig. 1
From: A network-centric approach to drugging TNF-induced NF-κB signaling
Transcriptional responses to compounds correlate with knockdowns of NF-κB pathway genes. a Schematic of the mature tumor necrosis factor (TNF) receptor 1 (TNFR1) complex, a cytoplasmic multi-protein complex that assembles following ligation of TNF to TNFR1. The color for each protein species in the complex is the average Pearson correlation between gene expression profiles for the species’ genetic knockdown and the transcriptional response to compounds 2 and 3. b Correlation between transcriptomic perturbations by compounds 1, 2, and 3 and the knockdown of genes functionally involved in NF-κB according to the KEGG PATHWAY Database. Pearson correlation color scale is shown (right). c Unbiased molecular docking predicts binding of compounds 2 (yellow) and 3 (magenta) to the TRADD-binding interface of TRAF2. Hydrogen bonds with key TRAF2 interface residues are indicated by dotted lines. Source data are provided as a Source Data file
