Fig. 6
From: Orthobunyavirus spike architecture and recognition by neutralizing antibodies
1C11 and 4B6 protect IFNAR-/- mice from lethal SBV infection. a, b Survival curves (a) and relative body weight development (b) of antibody-treated and untreated mice over the first nine days post infection (n = 6 per group). The mAbs had been administered 24 h prior to challenge infection. Weights are given as mean percentage ± s.d. c Viral genome loads at 3, 7, and 21 dpi or on the day when an unvaccinated animal had to be euthanized (fatalities). Horizontal bars represent mean values. The dashed line indicates the detection limit. Statistical analysis was performed using the Mann–Whitney rank sum test. **P < 0.01; n.s. not significant (P > 0.05). d Percentage of animals with N protein-specific antibodies at 21 dpi or on the day when an unvaccinated animal had to be euthanized. The numbers of seroconverted animals in each category is indicated. #Two of six mock-treated animals naturally succumbed to the infection and were thus not available for blood analysis. Source data are provided as a Source Data file
