Fig. 7
From: Orthobunyavirus spike architecture and recognition by neutralizing antibodies
The N-terminal variable half of SBV Gc mutates at structurally and antigenically critical sites in ruminant fetuses. a Relative surface conservation among the SBV group of OBVs, including SATV, DOUV, SHUV, and AINOV (see main text), mapped to the structure of the N-terminal half of SBV Gc. The sequences represent viruses from adult viremic cattle or from midges. b Relative surface conservation among 13 unique SBV aa sequences from adult viremic ruminants collected in 2011 or 2012. c Relative surface conservation among 38 unique SBV aa sequences from malformed newborn ruminants collected in 2011 or 2012 (Supplementary Data 2). The relative surface conservation is color-coded with blue for high similarity and orange for high divergence. Residues with high mutation frequency in aborted fetuses or malformed newborns are labeled and their nearest secondary-structure elements in the amino acid sequence are given in brackets. In all panels, the head domain is lifted off the stalk in order to expose the head/stalk interface area. #In the elongated conformation of the trimeric spike the footprint of the head on the stalk is shifted (dotted line) with respect to the V-shaped conformation of the crystal structure (closed line). The footprint of the stalk on the head is similar between the two conformations
