Fig. 5

Marker gene-based SNV profiles are comparable to those using whole genomes. a Pearson correlation coefficients for MG- and genome-based SNV profiles across species and biomes in the HMP (N = 2807) and ocean dataset (N = 139). Median correlations (Pearson’s r) are shown as horizontal lines and interquartile ranges as boxes. Whiskers extend at most 1.5 times the interquartile range. b Intra- and inter-individual distances of SNV profiles were compared using the area under the receiver operating characteristic curve (AU-ROC) to determine the degree of individuality of microbial strain populations for different human body sites (see also Supplementary Figure 17). Error bars delineate 95% confidence intervals after bootstrapping. Source data are provided as a Source Data file.