Fig. 5
From: Impact of pre-existing dengue immunity on human antibody and memory B cell responses to Zika
ZIKV infection elicits a strong type-specific binding response in serum antibodies. Analysis of the total ZIKV response in MBCs and serum from ZIKV-infected patients with no (DENV-naïve/ZIKV), one (DENV-ZIKV), or more than one (+DENV-ZIKV) prior DENV infection. a Proportion of ZIKV type-specific (TS) and cross-reactive (CR) responses over total ZIKV MBC response at ~8 months post-ZIKV infection. b Proportion of ZIKV type-specific (TS) and cross-reactive (CR) responses over total ZIKV serum antibody-binding response at ~8 months post-ZIKV infection. DENV-reactive antibodies were depleted from patient sera to obtain the proportion of the ZIKV response that is due to only ZIKV type-specific antibodies. c Correlation of the proportion of ZIKV TS responses in MBCs and serum. The median and IQR are shown for a and b. Significance was determined by Mann–Whitney test for a and b, and correlation analysis in c was performed using Spearman r test. *p < 0.05, **p < 0.01, ***p < 0.001. The sample size for each group is as follows: DENV-naïve/ZIKV MBC, n = 13 and serum n = 10; DENV-ZIKV, MBC n = 12 and serum n = 11; +DENV-ZIKV MBC n = 8 and serum n = 7
