Table 1 Baseline characteristics of the enrolled men with T2DM

From: Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes

Study part (n): group (n)

Part A (n = 27): Placebo onlya (n = 9)

Part A (n = 27): VEGF-A mRNA/placeboa (n = 18)

Part B (n = 15): VEGF-A mRNA/placebob (n = 15)

Age, years

 Median (range)

58.0 (47, 65)

58.5 (41, 65)

56.0 (44, 64)

Race, white

   

 n (%)

9 (100.0)

18 (100.0)

15 (100.0)

BMI, kg/m2

 Median (range)

30.80 (27.5–34.5)

29.40 (25.2–33.3)

30.10 (22.2–35.0)

Medical history, n (%)

[>30% in any group]

   

 Hypertension

5 (55.6)

6 (33.3)

11 (73.3)

 Hyperlipidemia

4 (44.4)

5 (27.8)

6 (40.0)

 Appendectomy

1 (11.1)

2 (11.1)

8 (53.3)

 Inguinal hernia repair

4 (44.4)

3 (16.7)

1 (6.7)

 Seasonal allergy

3 (33.3)

3 (16.7)

3 (20.0)

  1. BMI, body mass index; T2DM, type 2 diabetes mellitus; VEGF-A mRNA, vascular endothelial growth factor A modified messenger RNA
  2. aVEGF-A mRNA/placebo, placebo/VEGF-A mRNA, or placebo/placebo at sites 1/2
  3. bRandomized order of VEGF-A mRNA and placebo injections