Fig. 2 | Nature Communications

Fig. 2

From: Gamma oscillations in somatosensory cortex recruit prefrontal and descending serotonergic pathways in aversion and nociception

Fig. 2The alternative text for this image may have been generated using AI.

Mice with ongoing paw inflammation have increased gamma oscillatory power in the S1 hindlimb cortex (S1HL). a Time-frequency representation of spectral power in S1HL of naive mice (n = 11, left) and again 4 days after CFA injection in the contralateral hindpaw (right) during recording sessions without stimulation (grand mean, 15–25 episodes per animal). b Mean power in the theta (4–8 Hz), alpha (8–12 Hz), beta (15–29 Hz), gamma (30–100 Hz), low gamma (30–60 Hz) and high gamma (60–100 Hz) frequency bands for 9 s unstimulated episodes shown in a in the naive and CFA-induced inflammatory state (n = 11; *p < 0.05, two-way repeated measures ANOVA with Bonferroni multiple comparison test). c–f Quantification of oscillatory power in defined frequency bands for the 1 s pre-stimulation period and over 2 s post-stimulation (represented in 250 ms time bins) in the S1HL of naive and CFA-inflamed mice during all 0.6 g von Frey filament application trials irrespective of the response behavior (n = 7 per group in all panels; *p < 0.05 compared to naive pre-stimulation baseline, #p < 0.05 compared to own respective pre-stimulation baseline, two-way repeated measures ANOVA with Bonferroni multiple comparisons). Data are represented as mean ± S.E.M.

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