Fig. 5 | Nature Communications

Fig. 5

From: The Aryl hydrocarbon receptor mediates tobacco-induced PD-L1 expression and is associated with response to immunotherapy

Fig. 5

AhR expression is associated with clinical benefits of PD-1 blockade. a The expression of AhR and PD-L1 (detected by IHC) and response of the patients to pembrolizumab. b IRS of AhR and PD-L1 in patients achieved PR, SD, or PD. c A total of 422 genes (supplementary Table 1) were sequenced in 35 out of the 37 patients, and the number of mutated genes per sample are shown. Error bars, sd. P values in b, c, Student’s t test. d Clinical characteristics, AhR/PD-L1 IRS, TMB, and response of the patients to pembrolizumab. Objective response: PR partial response, SD stable disease, PD progression of disease. Histology: A adenocarcinoma, AS adenosquamous carcinoma, L lymphoepithelioma-like carcinoma of the lung, S squamous cell carcinoma. Gender: F female, M male. Smoking: Y yes, N no

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