Table 1 Reaction development and optimizations

From: Enantioselective Rhodium-Catalyzed Cycloisomerization of 1,6-Allenynes to access 5/6-Fused Bicycle[4.3.0]nonadienes

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  1. NBD, norbornadiene; DCE, 1,2-dicholoroethane; THF, tetrahydrofuran
  2. aAll the reactions were conducted with 1a (0.1 mmol) with an in situ generated ligand (10 mol%)-PPh3 (10 mol%)-Rh(I) (5 mol%) complex in the presence of Ag(I) salt (20 mol%) in degassed solvent at 40 °C unless otherwise noted
  3. bThe combined yield of 2a and 3a, isolated yields were reported
  4. cDetermined by 1H-NMR of the mixture
  5. dDetermined by HPLC using a chiral stationary phase, See Supplementary Figure 41
  6. e1,4-Dioxane
  7. fNo reaction
  8. gPCy3 was used as the additional ligand
  9. hWithout use of the additional ligand
  10. The bold values means the results under the optimal conditions
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