Fig. 3 | Nature Communications

Fig. 3

From: G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma

Fig. 3

ATRX deficiency induces chromosome breaks. a ATRX-deficient NHAs (shATRX1, passage 15) showed significantly increased chromosome breaks by cytogenetic analysis relative to ATRX-intact controls (shCon). b ATRX-mutant GSCs (08-0537) showed significantly increased chromosome breaks by cytogenetic analysis relative to ATRX wild-type GSCs (TS 603). c Quantified chromosome breaks in Atrx-intact and Atrx-KO mNPCs (also Tp53-/-, passage 10). In all cases, 10 sets of chromosomes were quantified. Error bars reflect SEM; P values determined by unpaired, two-tailed t-test

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