Fig. 4 | Nature Communications

Fig. 4

From: G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma

Fig. 4

ATRX deficiency induces clinically relevant copy number alterations. a Size distribution of CNAs in parental (P0), shCon (P5 and P15), and shATRX1 (P5 and P15) NHAs (three replicates each). In ATRX knockdown cells, large CNAs (>1 Mb) arise over passage number. b Size distribution of CNAs in IDHmut-noncodel gliomas (TCGA)2. c, d IGV plots for chromosome 12 (c) and 14 (d) comparing CNA regions in IDHmut-noncodel gliomas (above dotted line) to NHAs (below dotted line). Color scales indicate log2 copy number. e, f Kaplan–Meier curves for IDHmut-noncodel glioma patients with or without either 12p gain or 14q loss, showing significant differences in overall survival. P values determined by Log-rank (Mantel–Cox) test

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