Table 2 Heterogeneity in functional profiling of modules in the sponge core–microbiome network

Pairs	F statistic	R ²	p-value	Adjusted p-value	Significance
1 vs. 2	1.372646	0.03672862	0.188	0.685327436
1 vs. 3	3.345947	0.09205832	0.009	0.045931520	.
1 vs. 4	16.036242	0.18215501	0.001	0.006379378	*
1 vs. 7	9.448082	0.18014161	0.001	0.006379378	*
1 vs. 6	1.822294	0.04463967	0.080	0.340233479
1 vs. 5	1.403918	0.04617557	0.186	0.685327436
2 vs. 3	5.941705	0.18037029	0.003	0.016404114	.
2 vs. 4	23.547491	0.26296093	0.001	0.006379378	*
2 vs. 7	16.040983	0.30242620	0.001	0.006379378	*
2 vs. 6	3.107370	0.08605917	0.003	0.016404114	.
2 vs. 5	1.525886	0.06221531	0.138	0.556013133
3 vs. 4	13.359251	0.17495262	0.001	0.006379378	*
3 vs. 7	3.912138	0.10318959	0.010	0.047845333	.
3 vs. 6	10.089029	0.25166559	0.001	0.006379378	*
3 vs. 5	7.565526	0.27445606	0.001	0.006379378	*
4 vs. 7	18.998684	0.20651039	0.001	0.006379378	*
4 vs. 6	44.524645	0.39220246	0.001	0.006379378	*
4 vs. 5	28.084935	0.32250050	0.001	0.006379378	*
7 vs. 6	24.190476	0.37685460	0.001	0.006379378	*
7 vs. 5	20.280478	0.40334696	0.001	0.006379378	*
6 vs. 5	2.902114	0.10041183	0.022	0.099067984

Results of pairwise permutational analysis of variance (PERMANOVA) performed over the set of metabolic functions inferred for each module in the sponge core–microbiome network based on the microbiome. Significance codes: ‘*’ 0.01, ‘.’ 0.05, ‘ ’ 0.1

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