Table 1 Comparison of flourophosphines with various degrees of steric hindrance

From: Rapid one-step 18F-radiolabeling of biomolecules in aqueous media by organophosphine fluoride acceptors

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  1. Results of RCY are presented by means  ±  standard deviations (n  =  3)
  2. aP-F bond energy calculated by Gaussian 09
  3. bAll RCYs are experimental values acquired under the same conditions, where 1.0 μmol of precursor was dissolved in 100 μL of DMSO, 100 μL of [18F]F- aqueous solution from the cyclotron target was added, and the reaction was carried out at 75 °C for 15  min. All yields are presented at EOS without decay correction, and each experiment was repeated for 3 times
  4. cFraction of the intact 18F-labeled fluorophosphine synthons in the plasma of male BALB/c nude mice at 120  min after tail vein injection
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