Fig. 3
SERMs modulate in vivo microtubule organization. a hTERT-RPE1 cells were treated with indicated drugs for 3 h at 50 µM (an asterisk (*) indicates treatment with 500 nM) and immunostained for alpha-tubulin (green) and DNA (blue). Scale bar 20 µm. Each of the nine SERMs induced diverse microtubule defects to varying degrees, including abnormal mitotic spindles, microtubule bundling, and the formation of cytoplasmic microtubule rings. b The frequency of four specific microtubule effects observed (Supplementary Fig. 2) in each drug condition (from Supplementary Data 4). The average incidence of abnormalities per cells is quantified for each treatment (green bar)
