Fig. 3 | Nature Communications

Fig. 3

From: Transcriptional profiling of human microglia reveals grey–white matter heterogeneity and multiple sclerosis-associated changes

Fig. 3

Co-expression networks for microglia in grey and white matter (GM and WM, respectively) and in normal-appearing multiple sclerosis (MS) tissue. a Twenty-one modules identified by weighted gene co-expression network analysis are provided with their module–trait correlation and the amount of genes that belong to each module displayed between brackets. b, c Modules of interest for GM and WM regions and for MS GM or WM tissue are highlighted with top enriched hallmarks, Gene ontology terms, Kyoto Encyclopedia of Genes and Genomes pathways, and disease terms as well as top hubgenes with the highest connectivity provided. Module eigengenes (MEs) lightcyan and coral correlate to GM in control or in both control and MS microglia, respectively. MEs darkseagreen and black correlate to WM in control microglia or in both control and MS, respectively. MEs darkmagenta and purple correlate to MS WM or GM, respectively. d Heatmaps display the expression of each gene in modules of interest, based on Z-score

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