Fig. 4 | Nature Communications

Fig. 4

From: Transcriptional profiling of human microglia reveals grey–white matter heterogeneity and multiple sclerosis-associated changes

Fig. 4

Conservation of homeostatic gene expression in microglia from normal-appearing multiple sclerosis (MS) tissue. a, b Venn diagrams show hardly any overlap between homeostatic genes identified in mouse microglia15 and differentially expressed genes for grey matter (GM; n = 5) and white matter (WM; n = 10) MS microglia. c, d Expression of 25 homeostatic signature genes is amply changed in human microglia from both MS GM and WM, except for USP2 upregulation in GM and ADGRG1 downregulation in WM MS microglia. Two-way ANOVA: * adjusted p <0.05. e Flow cytometric analysis confirms downregulation of GPR56 protein expression in MS WM microglia (n = 6) compared to non-MS WM microglia (n = 8). Mann–Whitney U test: **p < 0.01. Bars show mean with standard deviation

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