Fig. 6
From: Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model
Immune activation gene signature predicts better overall survival in breast cancer patients. a Expressions of effector T-cell-specific genes were higher in Ly6C+CD8+ population compared with the Ly6C−CD8+ subset isolated from the spleen of EMT6 tumor-bearing mice and counterparts isolated from naive mice. *P < 0.05, **P < 0.005, ***P < 0.0005, one-way analysis of variance test. b, c Gene expression analyses of lung-derived Ly6C+ cell population from EMT6 tumor-bearing mice compared with naive or 4T1 tumor-bearing mice revealed 728 distinctly regulated genes. Top highly expressed genes are related to T-cell activation called “immune activated gene signature”. d Expressions of these immune-activated genes in primary EMT6 tumors at early time points suggest that early immune response. **P < 0.005, ***P < 0.0005, two-tailed Student’s t test. Results are presented as mean ± SD (n = 3). e–h Higher expression of immune-activated gene signature predicts better overall survival in breast cancer patients. Patients with TNBC subtype derive the highest survival benefit, while Luminal and HER2 + patients fail to show any benefit. i Elevated expression of immune-activated gene signature correlates with higher expression of CD8 mRNA in TNBC tumor samples
