Fig. 9
From: Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model
Illustration of key differences between the metastatic and non-invasive tumors. a The 4T1 tumor model effectively induces immunosuppressive MDCS accumulation by secretion of inflammatory cytokines such as G-CSF and that generates permissive pro-metastatic microenvironment. b The EMT6 tumor model, however, fails to induce MDSC accumulation and resulting in antitumor immune response that effectively eradicates disseminated tumor cells in distant organs
