Fig. 7 | Nature Communications

Fig. 7

From: Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons

Fig. 7

Schematic model of purinergic signalling from L-cells to local targets. ATP released together with GLP-1 and PYY from L-cells, exemplified here by angiotensin receptor stimulation, can activate purinergic receptors located on neighbouring enterocytes, potentially modulating fluid secretion by opening of Ca2+-sensitive K+ channels. ATP released from L-cells also targets local nerve terminals of vagal afferent neurons deriving from the nodose ganglion (brown cell) which express purinergic P2X3 receptors, providing ATP neurotransmitter mediated signalling pathway from the intestinal epithelium to the brainstem

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