Fig. 1 | Nature Communications

Fig. 1

From: Etv6 activates vegfa expression through positive and negative transcriptional regulatory networks in Xenopus embryos

Fig. 1The alternative text for this image may have been generated using AI.

Genome-wide occupancy of Etv6 in Xenopus somites at stage 22. a Experimental design of Etv6 ChIP-seq assay. The somites were dissected from stage 22 Xenopus laevis embryos, homogenized and fixed, and subjected to Etv6 ChIP-seq. NGS, next-generation sequencing. b Genomic distribution of the 9128 Etv6 ChIP-seq peaks throughout the X. laevis genome. NA, not annotated; TSS, transcription start site; TTS, transcription termination site. c Integrative genome viewer (IGV) showing examples of Etv6 ChIP-seq tracks. Etv6 binding is enriched in the TSS region of rimklb.S and Xelaev18005411m (red boxes) but not in the TSS region of tal1.L. Input is shown as control. The consensus peaks were generated using DiffBind; for the peak tracks of individual replicates, see Supplementary Figure 13. d De novo motif analysis of ETV6 peaks located in the TSS region. Five out of the 22 overrepresented motifs are shown

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