Fig. 5
From: Restoration of high-sensitivity and adapting vision with a cone opsin
Restoration of visually guided exploratory behavior by MW-opsin. a–d Open field behavioral arena containing two novel objects with traces of the first minute locomotion track from 3 representative animals per condition: untreated rd1 mice (a), rhodopsin expressing rd1 mice (b), MW-opsin expressing rd1 mice (c), and wt mice (d). e, f Total distance traveled and average velocity of mice during 10 min of exploration in the novel object behavior box. g–l Latency to exploration of first object (g), cumulative latency to exploration of the second object (h), velocity of travel to the first (i) and second object (j), distance traveled to first (k) and second object (l) for rd1-sham injected (dark gray) (n = 4), rd1 untreated (gray) (n = 13), rhodopsin (blue) (n = 11), MW-opsin (green) (n = 11) and wt (white) (n = 8). Values are mean + SEM. Statistical significance assessed using a two-tailed t test (*p < 0.05)
