Fig. 3

Distinct patterns of Index VI in bone and soft tissue tumors. a Values of Index VI differed significantly between malignant (sarcoma) tumors and the other samples in the validation and exploratory sets. The Index VI values of the discovery, training, and validation or exploratory sets were compared among various histological subtypes in b malignant (sarcoma), c intermediate, and d benign tumors. e The values of Index VI were also compared between sarcomas and the other eight cancers in the validation and exploratory sets. CS2,3 chondrosarcoma, grades II and III, DOS differentiated osteosarcoma, DCS differentiated chondrosarcoma, EWS Ewing sarcoma, OS osteosarcoma, MLS myxoid liposarcoma, MFS myxofibrosarcoma, USS/UPS undifferentiated spindle cell sarcoma/undifferentiated pleomorphic sarcoma, RMS rhabdomyosarcoma, SS synovial sarcoma, DDLPS dedifferentiated liposarcoma, ACT/CS1 atypical cartilaginous tumor/chondrosarcoma, grade I, ABC aneurysmal bone cyst, GCT giant cell tumor of bone, LCH Langerhans cell histiocytosis, ATL/WDLPS atypical lipomatous tumor/well-differentiated liposarcoma, DFSP dermatofibrosarcoma protuberans, Desmoid desmoid-type fibromatosis, SFT solitary fibrous tumor, SBC simple bone cyst, TGCT tenosynovial giant cell tumor