Fig. 4 | Nature Communications

Fig. 4

From: Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy

Fig. 4

Biodegradation of HMON and X-ray-activated •OH generation. a–d TEM images of thioether-hybridized HMON dispersed in PBS with 10 mM GSH for 1 day (a), 3 days (b), 7 days (c), and 14 days (d). Scale bar: 50 nm. e Degradation curve of thioether-hybridized HMON in PBS with 10 mM GSH within 14 days. n = 3, mean ± s.d. f Fluorescence emission spectra of TAOH with different concentrations. g Standard curve for the linear relation between the concentration of TAOH and its fluorescence intensity at λ = 430 nm. h Schematic of X-ray-activated cleavage of peroxy bond within TBHP (encapsulated in the cavity of HMOP) for generation of •OH. i Fluorescence spectra of TAOH (oxidized TA) subjected to varied doses (0, 2, 4, 6 Gy) of X-ray irradiation with or without HMOP-TBHP. j The •OH concentrations calculated by •OH-triggered oxidation of TA into 2-hydroxyterephalic acid (TAOH)

Back to article page