Fig. 1
From: Clonal architectures predict clinical outcome in clear cell renal cell carcinoma
The distribution of mutational signatures across different cohorts. a Five distinct mutational signatures identified by NMF analysis of the matrix of mutation proportion across tumors from different populations. b Comparison of mutational signatures between clonal and subclonal mutations. Enrichment of mutational signatures between clonal and subclonal mutations was determined by Fisher test of the relative contribution of each signature in all patients. c Mutational exposures (number of mutations) attributed to each mutation signature in each patient
