Fig. 1
Meta-analysis and molecular gradients. a Correlation matrix of centroid profiles of all clusters from the different classifications. b Estimation of the E-score and S-score and classification subtype predictions in all available tumor tissue samples (442 samples). The samples were ordered based on their E-score and S-score ratios. c–f Boxplots of the E-score and S-score according to the histology results (c), CIT subtype predictions (d), Bueno subtype predictions (e), and TCGA subtype predictions (f). Significance in the T-test comparing the E-score and S-score in each modality is shown (*P value < 0.05, **P value < 10e−9, NS, not significant). For all boxplots (c, d, e, f), bottom and top of boxes are the first and third quartiles of the data, respectively, and whiskers represent the lowest (respectively highest) data point still within 1.5 interquartile range of the lower (respectively upper) quartile. Center line represents the median value
