Fig. 1
From: Multiple ABCB1 transcriptional fusions in drug resistant high-grade serous ovarian and breast cancer
ABCB1 in recurrent HGSC and breast cancer patients. a Patients ranked by ABCB1 expression level in recurrent HGSC samples (n = 108), presence of ABCB1 transcriptional fusions was observed in 20 patients, the bar colour indicates the fusions present. Gene structure of 10 of the 13 fusion partner genes is shown. b Schematic representation of the structure of a majority of the transcriptional fusions identified in which non-coding exons of partner genes (red) were fused to exon 2 onwards of ABCB1 (green). c Clustering of breakpoints at the 3′ end of intron 1 of ABCB1, green triangles indicate SLC25A40–ABCB1 fusion breakpoints, red are other fusion partners. d Schematic representation of the structure of the SV involving ABCB1 in Patient 9. e Breast cancer patients ranked by ABCB1 expression in recurrent or end-stage samples (n = 30 patients, 45 samples). ABCB1 fusions were observed in nine patients (blue or green dots)
