Fig. 3

Identification of the Chr15 79–87 Mb region having genetic linkage to the skin tumour phenotype. a Schematic of the recombined Chr15 with varying 129P2 and FVB/N background in skin tumour bearing mice (blue: 129P2, green: FVB/N background and grey: region of crossover); relevant microsatellite markers used are indicated on top; below a blowup of the relevant region). b Number of skin tumours on individual Cdkn2ab^−/− mice homozygous FVB/N (green) Chr15 85 Mb or FVB/N;129P2 (blue) for region Chr 15 85 Mb (Chr15*). c Tumour spectrum of Cdkn2ab^−/− mice as mentioned in b. d Frequency of squamous metaplasia in the lungs of Cdkn2ab^−/− mice as mentioned in b. e Kaplan–Meier curve showing skin tumour-free survival of Cdkn2ab mutant mice FVB/N;129P2 for the Chr 15; 85 Mb region; red line: Cdkn2ab^−/−: deficient for p15^Ink4b, p16^Ink4a and p19^Arf; green: Cdkn2b^−/−;Arf^+/−;Ink4a^−/−: deficient for p15^Ink4b and p16^Ink4a, proficient for p19^Arf; blue: Cdkn2b^−/−;Arf^−/−;Ink4a^+/-: deficient for p15^Ink4b and p19^Arf, proficient for p16^Ink4a; orange: Cdkn2b^+/−;Cdkn2a^−/−: deficient for p16^Ink4a and p19^Arf, proficient for p15^Ink4b. Statistical analysis (Unpaired t-test): ns: **p < 0.01, ***p < 0.001