Fig. 1 | Nature Communications

Fig. 1

From: Semi-solid prodrug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs within combination HIV therapies

Fig. 1

Schematic overview of long-acting semi-solid prodrug nanoparticle (SSPN) strategy. Emulsion-templated freeze drying (ETFD) screening is applied to a range of emtrictabine (FTC) prodrugs bearing bio-reversible carbonate and carbamate masking groups. SSPNs are released into aqueous media after rapid dispersion of ETFD monoliths into water, resulting in a dispersion of SSPNs slowly releasing prodrug under physiologically relevant conditions and subsequent bioactivation to release the parent FTC

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