Fig. 2 | Nature Communications

Fig. 2

From: Semi-solid prodrug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs within combination HIV therapies

Fig. 2

In vitro metabolism of emtrictabin (FTC) prodrugs under physiologically relevant conditions. a Initial rates of esterase-mediated hydrolysis of 5’-carbonate (1 mM, 1–8) to generate corresponding carbamates, and initial rates of hydrolysis of carbamates (1 mM, 9–16), resembling capecitabine, to generate FTC was monitored in undiluted human plasma (b), muscle S9 (c), and liver S9 (d) fractions. The light blue band represents the mean ± SD for carbamate cleavage from capecitabine

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