Fig. 1

Overall structure of MexAB–OprM. Single-particle cryo-EM reconstruction (top) and model of MexAB–OprM (bottom) in the 0° state (a) or 60° state (b) viewed from the periplasmic space (a, b) or from the outside the cell (c, d). The OprM protomers are colored in cyan, salmon, and lemon. MexA protomers are colored in magenta (SC protomer) or orange (LC protomer). MexB protomers in the Access, Resting, and Extrusion states are colored in green, blue, and red, respectively