Fig. 5
Conformational change of MexB from the Resting state to the Binding state. a Superposition of the Resting state in the cryo-EM structure (blue), the Binding state in the crystal structure (PDB ID: 3w9i, gray), and the Binding state in the cryo-EM structure (cyan). Gate loops are colored in red. Red arrows indicate conformational changes of the gate loop. b–d Visualization of channels to the distal binding pocket, generated using caver v. 3.0.145. Shown are the Resting state in the cryo-EM structure (b), the Binding state in the crystal structure (c), and the Binding state in the cryo-EM structure (d). Channels are shown as yellow spheres with diameters greater than 1.6 Å (top panels) and 2.0 Å (bottom panels). Atomic models are shown in ribbon diagram, and surface views are transparent with the same color as in a. Gate loops are colored in red
