Fig. 3
A FadRSa–DNA cocrystal structure reveals an important role for hydrophobic interactions. a Cartoon representation of the cocrystal structure of FadRSa in complex with the operator site in the fadRSa promoter region. Different FadRSa subunits are labeled A–E, each dimer is colored differently with subunits A and B belonging to the same dimer while being displayed in a darker and lighter green, respectively, for the sake of clarity. b Detailed map of interactions identified in the FadRSa–DNA cocrystal structure, summarizing Supplementary Data 1. c Zoom of the interface between subunit E and the X–Y DNA duplex, with emphasis on interactions established by residues Tyr47, Tyr51, and Phe52. Hydrogen bonds are indicated by black and hydrophobic interactions by gray dashed lines. Bases are labeled with those belonging to chain Y being displayed with a prime. d Zoom of the interaction between subunits E (in orange) and B (in green). Weak electrostatic interactions are indicated with dashed lines
