Fig. 2
From: Cortex-wide neural interfacing via transparent polymer skulls
Chronic implantation of See-Shells. a Photographs of a Thy1-GCaMP6f mouse 6 and 36 weeks after implantation with See-Shells. Scale bars indicate 2 mm. b The design can be modified to fit different skull morphologies. Photographs of a tg/tg mouse 10 and 30 weeks after implantation. Scale bar indicates 2 mm. c Immunohistology analysis of mice chronically implanted with See-Shells for 5 weeks compared to age-matched non-surgical control mice at ~2.0 mm posterior to bregma and 1.5 mm lateral to the midline. Coronal slices were immunolabeled with anti-glial fibrillary acidic protein (anti-GFAP) and DAPI. No activated astrocytes were observed in any of the mice assessed. Scale bar indicates 500 µm. d Bar plots overlaid with the dot plots of mean GFAP fluorescence measured in 21 regions of interest (ROIs) in See-Shell implanted and non-surgical control mice. Error bars indicate s.d.
