Fig. 7 | Nature Communications

Fig. 7

From: Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue

Fig. 7The alternative text for this image may have been generated using AI.

p110αDEL mice accumulate less weight with age. a, b Body weight gain over time in female (a) and male (b) p110αDEL and p110αFLOX mice. The average body weight of each group of mice between 8 and 26 months of age were compared by unpaired t test. n = 66 per genotype for male; n = 76 p110αFLOX and 58 p110αDEL for female. c Epididymal WAT and interscapular BAT mass of 1.5- and 2-year-old male mice. n = 10 per genotype for WAT; n = 8 per genotype for BAT. d Food intake of approximately 1-year-old mice. Each data point represents an average measurement from a single cage. Female mice (29 p110αFLOX and 20 p110αDEL) were distributed in 10 cages per genotype (n = 10) and male mice (22 p110αFLOX and 24 p110αDEL) mice were distributed in 12 cages per genotype (n = 12). Data are presented as mean ± SEM. Statistical analysis: unpaired two-tailed t test. *p < 0.05; **p < 0.01

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