Fig. 6
GPS2 expression associates with NASH and fibrosis in human. a Flowchart representing the analysis of microarray results in the human liver biopsies. b Heatmap representing the rho correlation coefficient of GPS2 and other core subunits with NASH-regulated genes in human NASH liver biopsies. c, d Correlation analysis of GPS2 mRNA level with (c) TGFB and (d) TIMP1 in human NAFLD liver samples (GSE49541), n = 72, non-parametric Spearman’s test. e GPS2 mRNA level in non-fibrosis and fibrosis liver biopsies in the NASH subjects, n(NASH non-fibrosis) = 74, n(NASH fibrosis) = 24, unpaired nonparametric Mann–Whitney test. f GPS2 mRNA level in NASH after weight loss in paired obese subjects, n = 54, paired nonparametric Wilcoxon matched-pairs signed rank test. g Heatmap representing the rho correlation coefficient of GPS2 and PPARA with NASH-regulated genes in human NASH liver biospies (n = 104). h Model illustrating the causal relationship between GPS2 expression and PPARα function in hepatocytes in the context of fatty liver disease. All data are represented as mean ± s.e.m. *P < 0.05, **P < 0.01, ***P < 0.001
