Fig. 5
Changes in ventrolateral PFC (VLPFC) theta power predict clinical outcomes. a, c, e, g Clinical outcomes vs. behavioral and neural changes. Panels (a, c) show change in Montgomery–Åsberg Depression Rating Scale (MADRS, where negative values indicate improvement); e, g show hypomania. Y axes are a, e the DBS-induced response time (RT) difference for each subject or c, g theta power difference during the period covered by the Fig. 3c cluster. Lines represent a robust linear regression. Circles represent subjects with primary diagnosis of MDD, squares represent subjects with primary diagnosis of OCD. Shaded areas are confidence bounds from 1000 bootstraps. “r” represents Pearson correlation, p-value via Fisher Z-transformation. b, d, f, h Receiver operating characteristic (ROC) curves for clinical response prediction. Confidence interval for area under the curve (AUC) is from 1000 bootstrap draws
