Table 1 Subject characteristics

From: Deep brain stimulation of the internal capsule enhances human cognitive control and prefrontal cortex function

Diagnosis

Age/sex

YBOCS BL

YBOCS FU

MADRS BL

MADRS FU

Responder

Task EEG

Rest EEG

Stim Freq

OCD

30/F

34

12

34

11

Y

Y

N

130

OCD

30/F

31

27

2

3

Y

Y

Y

130

MDD

40/F

N/A

N/A

44

11

Y

N

N

130

MDD

30/F

N/A

N/A

35

28

N

N

N

130

MDD

60/F

N/A

N/A

44

4

Y

N

N

130

MDD

50/M

N/A

N/A

33

10

Y

Y

Y

130

MDD

60/M

N/A

N/A

33

10

N

Y

N

100

MDD

50/F

N/A

N/A

42

29

N

Y

N

90

MDD

60/M

N/A

N/A

36

10

N

Y

N

130

MDD

50/F

N/A

N/A

42

28

Y

N

Y

130

MDD

50/M

N/A

N/A

38

24

N

Y

Y

50

MDD

60/M

N/A

N/A

34

9

Y

Y

Y

120

MDD

70/F

N/A

N/A

38

30

N

N

N

130

MDD

50/M

N/A

N/A

35

38

N

N

N

100

  1. Ages have been rounded to the nearest decade to mask identities. “Diagnosis” refers to the primary indication for receiving VCVS DBS. YBOCS scores were not collected for subjects whose primary clinical complaint was not OCD. The “Responder” column indicates whether the subject achieved clinical response at any point during his/her clinical trial; the criterion was a 50% drop in MADRS or a 35% drop in YBOCS. This may not have corresponded to the score at the time of study data collection. Response prediction analyses were based on the score at the time of recording for this study, as this was more likely to correlate to the measured biomarkers. The “Task EEG” and “Rest EEG” columns indicate subjects who contributed technically adequate EEG for MSIT-related and resting-state analysis, respectively. All subjects underwent recordings, but some could not be analyzed due to excessive artifact, most commonly from vocalization or substantial head/face muscle activation. “Stim Freq” gives the frequency of DBS, in Hz
  2. MDD major depressive disorder, OCD obsessive–compulsive disorder, YBOCS Yale-Brown obsessive–compulsive scale, MADRS Montgomery–Asberg depression rating scale, BL baseline (just before implant), FU follow-up (date of EEG recording or nearest clinical visit)
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