Fig. 4

Results of KEGG pathway enrichment analysis for the genes in each of the three significantly pheromone-sensitive transcriptional modules. The gene universe was defined as all genes for which we found an ortholog in all four species (i.e. the set that was used to discover these co-expressed modules). All KEGG terms shown in green were significantly enriched (p < 0.05), and those shown in purple remained significant after correction for multiple testing. Fold enrichment was calculated as the proportion of genes associated with the focal KEGG term in the module, divided by the equivalent proportion in the gene universe. Supplementary Figs. 6–8 show equivalent results for GO terms