Fig. 6 | Nature Communications

Fig. 6

From: A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers

Fig. 6The alternative text for this image may have been generated using AI.

STAG2 deficiency in human cancer cells creates a synthetic lethality with STAG1, whereas the core cohesin subunits SMC3, SMC1A, and RAD21 are required genes in human cancer cells independent of STAG2 status. a Quantitation of survival from lentiviral shRNA depletion of core cohesin subunits in four pairs of STAG2 isogenic human cells (H4 glioblastoma, 42MGBA glioblastoma, TC-106 Ewing sarcoma, and RPE shTP53). Each data point is the mean of 8 replicates from 2 independent experiments, and error bars show standard error of the mean. b Representative phase contrast images of STAG2 isogenic TC-106 Ewing sarcoma cells showing synthetic lethality of STAG2 inactivation with shRNA depletion of STAG1

Back to article page