Fig. 5
From: A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice
Features of regions aberrantly methylated by DNMT3AD329A. a Percentages of hypermethylated and hypomethylated tiles (100-CpG) falling within the genomic features indicated compared with a random set of 100-CpG tiles (Supplementary Data 14). n (tiles) indicated on top of the bars. CGI: CpG island. b Distribution of methylation values over DNA methylation canyon probes60 in Dnmt3a+/+ and Dnmt3aΔ/D329A mice. n = 779, Mann–Whitney test (p < 0.01, UA = 432,773, z = −14.57). Boxplots show median value and 25–75th percentiles, whiskers show lowest and highest observation, excluding outliers. Source data are provided in Supplementary Data 12. c GO analysis of genes overlapping differentially methylated tiles. Unless there were fewer significant terms, the top 8 most significant terms per category are shown. Benjamini–Hochberg corrected p-value < 0.01 was used as a threshold. DMR differentially methylated region
