Fig. 1
From: L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction
Crystal structures of BasC. a, b Crystal structure of BasC apo in complex with nanobody 74 (Nb74) at 2.9 Å (PDB ID 6F2G). Helices are colored blue to red from the N-termini and Nb74 is shown in magenta. c, d Crystal structure of BasC-Nb74 in complex with 2-AIB at 3.4 Å (PDB ID 6F2W). Helices are colored as in a, b, and the protein surface is depicted in light gray. The sagittal plane shows the substrate 2-AIB (orange) at the end of the vestibule open to the cytoplasm. d Detail of region squared in c showing the residues in the thick barrier that prevents the substrate from accessing the extracellular medium
