Fig. 2
From: GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures
Repression of miR-196a-5p target genes by MIR196A2 C-allele or T-allele inserts. a–c Volcano plot shown for all pair-wise comparisons of cells with MIR196A2 C-allele or T-allele inserts and empty vector controls. In each comparison, red colored dots indicate the fourteen miR-196a-5p target genes. a C-allele compared with empty vector insert, (b) T-allele compared with empty vector insert, and (c) C-allele compared with T-allele. Negative log2-fold values reflect downregulation with miRNA insert and in a and b, whereas negative log2-fold values reflect downregulation of the C-allele in c. d Distribution of log2 fold-change values derived from the comparison of C-allele and T-allele transfected cells (negative log2 fold represents downregulation of the C-allele). The red and black curves represents the density distribution for the fourteen high-confidence miR-196a-5p target genes and other non-targets, respectively. The direction of effect is indicated below the x-axis by an arrow. Source data are provided as a Source Data file
