Table 1 Lead variants for novel eGFR loci from meta-analysis
From: Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis
Chr | Pos (hg19) | rsID | Ref | Alt | Freqa | N | P-value | Directiona | Prioritized genes |
|---|---|---|---|---|---|---|---|---|---|
1 | 10733081 | rs284316 | T | C | 0.3331 | 196273 | 1.50 × 10−9 | + | CASZ1 |
1 | 100808363 | rs11166440 | A | G | 0.4119 | 350504 | 7.07 × 10−9 | − | CDC14A |
1 | 180905694 | rs3795503 | T | C | 0.6017 | 350504 | 7.54 × 10−13 | − | KIAA1614 |
1 | 227085824 | rs1800674 | A | G | 0.5615 | 350504 | 4.23 × 10−8 | − | ADCK3 |
2 | 18679586 | rs10856778 | C | G | 0.8311 | 350504 | 1.04 × 10−9 | + | LOC105373454 |
2 | 43441169 | rs35136921 | T | C | 0.4564 | 177995 | 2.74 × 10−11 | + | THADA |
2 | 54574942 | rs1405833 | C | G | 0.2733 | 350504 | 5.10 × 10−10 | − | C2orf73 |
2 | 178146362 | rs17581525 | C | G | 0.1889 | 350504 | 6.11 × 10−11 | + | AC074286.1 |
2 | 191278341 | rs6725814 | A | G | 0.261 | 350504 | 3.39 × 10−8 | + | MFSD6 |
2 | 230612451 | rs6756038 | A | G | 0.7353 | 350504 | 4.72 × 10−9 | − | TRIP12 |
3 | 38479475 | rs7429308 | T | C | 0.4951 | 350504 | 4.90 × 10−11 | − | ACVR2B, XYLB |
3 | 193816778 | rs10933714 | A | T | 0.5232 | 350504 | 2.81 × 10−9 | − | LINC02028 |
3 | 195477791 | rs2291652 | A | G | 0.4385 | 347321 | 2.36 × 10−8 | − | SDHAP2, MUC20, RP11-141C7.4, SDHAP1, MUC4, MIR570 |
4 | 23758662 | rs73243607 | T | C | 0.962 | 349244 | 3.37 × 10−8 | − | PPARGC1A |
5 | 107459529 | rs12652687 | T | C | 0.1447 | 349666 | 3.61 × 10−8 | − | FBXL17 |
6 | 24354045 | rs3765502 | T | C | 0.2351 | 347321 | 4.01 × 10−8 | − | DCDC2 |
6 | 107172979 | rs7766720 | T | C | 0.1424 | 350503 | 4.13 × 10−8 | − | LINC02532 |
7 | 50737852 | rs73116822 | T | C | 0.9282 | 349244 | 2.71 × 10−9 | + | GRB10 |
7 | 56072841 | rs4948100 | T | C | 0.3796 | 350504 | 1.17 × 10−8 | + | ZNF713, PSPH, CCT6A, GBAS |
7 | 128737958 | rs56088330 | A | T | 0.6814 | 350504 | 8.12 × 10−10 | + | RP11-286H14.4, TSPAN33 |
8 | 9074223 | rs7006504 | T | C | 0.297 | 206846 | 1.91 × 10−9 | − | PPP1R3B, ENSG00000254235, ENSG00000182319, RP11-10A14.5 |
8 | 32399662 | rs4489283 | T | C | 0.6897 | 349668 | 2.47 × 10−9 | + | RP11-1002K11.1 |
8 | 126477978 | rs2001945 | C | G | 0.4361 | 350504 | 4.37 × 10−11 | + | TRIB1 |
8 | 134332960 | rs10283362 | T | C | 0.8607 | 350504 | 2.04 × 10−8 | − | NDRG1 |
9 | 34130435 | rs61237993 | A | G | 0.654 | 350501 | 1.85 × 10−8 | − | DCAF12, UBE2R2 |
9 | 112206404 | rs10816812 | A | T | 0.6295 | 350501 | 1.00 × 10−8 | + | PTPN3 |
9 | 136146597 | rs550057 | T | C | 0.7393 | 350501 | 1.58 × 10−9 | − | ABO |
9 | 139107879 | rs11103387 | T | C | 0.7296 | 339928 | 8.07 × 10−10 | − | QSOX2 |
10 | 35171118 | rs11010013 | A | G | 0.6928 | 323766 | 1.50 × 10−8 | − | PARD3 |
10 | 79253261 | rs3127447 | A | C | 0.3283 | 349675 | 3.04 × 10−8 | + | KCNMA1 |
10 | 94810665 | rs856534 | A | G | 0.4342 | 347320 | 1.23 × 10−9 | + | EXOC6, CYP26C1 |
10 | 126418782 | rs11245344 | T | C | 0.4673 | 350504 | 3.37 × 10−11 | + | METTL10 |
11 | 68883556 | rs7131509 | T | C | 0.5311 | 350503 | 2.76 × 10−10 | − | TPCN2, LOC107984345 |
12 | 48736985 | rs2732481 | T | G | 0.2444 | 203655 | 1.82 × 10−9 | − | ZNF641 |
13 | 48654455 | rs9534949 | C | G | 0.6165 | 350503 | 4.84 × 10−9 | + | NUDT15, MED4-AS1, LINC00562 |
14 | 50735947 | rs72683923 | T | C | 0.0109 | 205585 | 2.98 × 10−8 | + | SOS2, L2HGDH |
15 | 39274261 | rs8026431 | A | C | 0.6364 | 350504 | 3.13 × 10−9 | − | LOC105370781 |
15 | 57830151 | rs117047297 | T | C | 0.9836 | 205586 | 3.16 × 10−8 | − | CGNL1 |
15 | 63634405 | rs1075456 | T | G | 0.6601 | 350504 | 3.05 × 10−9 | − | LACTB |
15 | 67561355 | rs12443279 | C | G | 0.3495 | 350504 | 3.03 × 10−8 | − | SMAD3 |
16 | 69718112 | rs77944668 | A | G | 0.6984 | 350504 | 1.45 × 10−8 | − | NFAT5, NQO1 |
16 | 73024276 | rs1858800 | T | C | 0.761 | 347323 | 1.82 × 10−8 | − | ZFHX3 |
16 | 79938996 | rs35286975 | C | G | 0.7933 | 350504 | 1.94 × 10−10 | − | MAF |
17 | 34950239 | rs12937411 | T | C | 0.6134 | 350502 | 1.62 × 10−10 | − | MYO19, DHRS11 |
19 | 18384950 | rs1075403 | T | G | 0.6992 | 348391 | 1.57 × 10−10 | − | JUND, KIAA1683 |
19 | 49217305 | rs281386 | A | G | 0.591 | 350504 | 4.77 × 10−8 | + | RASIP1, FUT2 |
20 | 62336334 | rs1758206 | T | C | 0.8245 | 204319 | 1.51 × 10−9 | + | ZGPAT, LIME1 |
21 | 16582710 | rs56038390 | A | G | 0.3014 | 350504 | 1.28 × 10−9 | − | NRIP1 |
21 | 35356706 | rs2834317 | A | G | 0.8977 | 350504 | 1.58 × 10−8 | + | LOC105372790 |
22 | 38600542 | rs2267373 | T | C | 0.3949 | 350504 | 2.65 × 10−10 | + | MAFF |
X | 18597869 | rs4825261 | A | C | 0.7148 | 96329 | 1.36 × 10−9 | − | CDKL5 |
X | 118630622 | rs454741 | A | G | 0.641 | 239987 | 5.15 × 10−10 | − | SLC25A43, CXorf56 |
X | 133808916 | rs11796053 | A | G | 0.4934 | 239987 | 4.93 × 10−8 | + | HPRT1 |
