Fig. 3
From: Cryo-EM structures of the pore-forming A subunit from the Yersinia entomophaga ABC toxin
Properties of the encapsulated YenTcA translocation pore. a A central section of the YenTcA pre-pore structure highlighting the pentameric translocation pore (yellow) as well as the neuraminidase-like domains that close the bottom of the complex (purple). b, c The translocation pore has a maximum radius of 15 Å and narrows towards the bottom, constricted by H996 (also shown as viewed from above in d) and L990. In b, d, the helices are coloured by protomer. e The extended hairpin loop structure of the neuraminidase-like domain that seals the pore (highlighted in purple). The loop sequence in particular is not well conserved with the equivalent sequences of TcA proteins from other ABC toxins
